Famous Scientists

  • Home
  • Top 100 Scientists
  • List of Scientists
  • Blog

Beating Antibiotic-Resistant Bacteria – a Breakthrough

By The Doc

Gram-negative bacteria such as those responsible for salmonella, meningitis, heliobacter, legionella, gonorrhea, and cholera cause debilitating diseases and death in people who become infected.

Legionella Pneumophila

Legionella Pneumophila

Worryingly, these bacteria are building ever stronger defenses against our stocks of antibiotic drugs. At some stage, they will become totally resistant to our existing drugs. When this happens, we will enter a nightmarish world in which minor cuts and infections could quickly become fatal.

Gram-negative bacteria have a lipopolysaccharide outer coating whose impermeability assists the bugs in fending off attacks from antibiotics. You could think of this coating as full body-armor.

This coating is called LPS, consisting of lipid A, core polysaccharide, and O antigen. It has been growing increasingly impermeable as bugs follow an evolutionary pathway to defeat our antibiotics. The armor is getting very strong.

The journal Nature has reported that medical researchers from the University of East Anglia’s Norwich Medical School in the United Kingdom have found a way to block the pathway the bacteria use to put this outer coating together. One of the lead researchers commented:

‘This is a giant leap forward in the fight against superbugs. This discovery doesn’t come a moment too soon.’

Researchers have discovered that a protein called LptDE is vital in building the bacteria’s LPS outer coating of armor. They are excited by the fact that the same mechanism is used in all gram-negative bacteria.

This means, if you can find a way to disrupt the LPS outer coating being built in one type of gram-negative bacteria, it should work in all such bacteria.

The preferred method of disruption is to find a drug molecule smaller than the LptDE protein that builds the coating. Importantly, this drug molecule would not need to get inside a bacterial cell to disrupt the building of the cell coating.

The weakened cell coating would allow bugs to be attacked more easily both by our immune cell and antibiotic drugs.

Another aspect that makes the work so vital is that it offers a method which can potentially overcome the new strains of superbugs which are causing serious problems in many hospitals. Too many patients are getting ill in the hospitals where they are meant to get better.

Health experts have said that within a decade or two, routine surgical operations could lead to a large number of deaths, because of widespread, untreatable infections. It would be a return to the days when there were no antibiotics and life was something of a lottery.

The work on disrupting the LPS coating is at an early stage, but it’s encouraging that a viable route has now been identified so that we can continue taking the fight to our microscopic enemies.

Advertisements
More from FamousScientists.org:
  • alexander fleming
    Alexander Fleming
  • selman waksman
    Selman Waksman
  • Barry Marshall
    Barry Marshall
  • howard florey
    Howard Florey
Advertisements

Search Famous Scientists

Scientist of the Week

  • Linda Buck: Discovered how we smell things

Recent Scientists of the Week

  • Jan Ingenhousz: Discovered photosynthesis
  • Barry Marshall: Overturned the Medical Establishment
  • Linus Pauling: Maverick Giant of Chemistry
  • William Röntgen: The Discovery of X-rays
  • Howard Florey: Brought penicillin to the world
  • Henrietta Leavitt: The key to the size of the universe
  • Archimedes: A mind beyond his time
  • Stanley Milgram: The infamous Obedience Experiments
  • C. V. Raman: Color change allows harm-free health check of living cells
  • Rosalind Franklin: Shape-shifting DNA
  • Robert Boyle: A new science is born: chemistry
  • Carl Woese: Rewrote Earth’s history of life
  • Alfred Wegener: Shunned after he discovered that continents move
  • Henri Poincaré: Is the solar system stable?
  • Polly Matzinger: The dog whisperer who rewrote our immune system’s rules
  • Otto Guericke: In the 1600s found that space is a vacuum
  • Alister Hardy: Aquatic ape theory: our species evolved in water
  • Elizebeth Friedman: Became the world’s most famous codebreaker
  • Evangelista Torricelli: We live at the bottom of a tremendously heavy sea of air
  • Eudoxus: The first mathematical model of the universe
  • James Black: Revolutionized drug design with the Beta-blocker
  • Inge Lehmann: Discovered our planet’s solid inner core
  • Chen-Ning Yang: Shattered a fundamental belief of physicists
  • Robert Hooke: Unveiled the spectacular microscopic world
  • Barbara McClintock: A Nobel Prize after years of rejection
  • Pythagoras: The cult of numbers and the need for proof
  • J. J. Thomson: Discovered the electron
  • Johannes Kepler: Solved the mystery of the planets
  • Dmitri Mendeleev: Discovered 8 new chemical elements by thinking
  • Maurice Hilleman: Record breaking inventor of over 40 vaccines
  • Marie Curie: Won – uniquely – both the chemistry & physics Nobel Prizes
  • Jacques Cousteau: Marine pioneer, inventor, Oscar winner
  • Niels Bohr: Founded the bizarre science of quantum mechanics
  • Srinivasa Ramanujan: Untrained genius of mathematics
  • Milutin Milankovic: Proved Earth’s climate is regulated by its orbit
  • Antoine Lavoisier: The giant of chemistry who was executed
  • Emmy Noether: The greatest of female mathematicians, she unlocked a secret of the universe
  • Wilder Penfield: Pioneer of brain surgery; mapped the brain’s functions
  • Charles Nicolle: Eradicated typhus epidemics
  • Samuel Morse: The telegraph and Morse code
  • Jane Goodall: Major discoveries in chimpanzee behavior
  • John Philoponus: 6th century anticipation of Galileo and Newton
  • William Perkin: Youthful curiosity brought the color purple to all
  • Democritus: Atomic theory BC and a universe of diverse inhabited worlds
  • Susumu Tonegawa: Discovered how our bodies make millions of different antibodies
  • Cecilia Payne: Discovered that stars are almost entirely hydrogen and helium

Top 100 Scientists

  • Our Top 100 Scientists

Our Most Popular Scientists

  • Astronomers
  • Biologists & Health Scientists
  • Chemists
  • Geologists and Paleontologists
  • Mathematicians
  • Physicists
  • Scientists in Ancient Times

List of Scientists

  • Alphabetical List

Recent Posts

  • Perfect Numbers and our Tiny Universe
  • What Happens when the Universe chooses its own Units?
  • Hipparchus and the 2000 Year-Old Clue
  • Darwin Pleaded for Cheaper Origin of Species
  • You Will Die For Showing I’m Wrong!
  • Getting Through Hard Times – The Triumph of Stoic Philosophy
  • Johannes Kepler, God, and the Solar System
  • Charles Babbage and the Vengeance of Organ-Grinders
  • Howard Robertson – the Man who Proved Einstein Wrong
  • Susskind, Alice, and Wave-Particle Gullibility




Alphabetical List of Scientists

Louis Agassiz | Maria Gaetana Agnesi | Al-BattaniAbu Nasr Al-Farabi | Alhazen | Jim Al-Khalili | Muhammad ibn Musa al-Khwarizmi | Mihailo Petrovic Alas | Angel Alcala | Salim Ali | Luis Alvarez | Andre Marie Ampère | Anaximander | Carl Anderson | Mary Anning | Virginia Apgar | Archimedes | Agnes Arber | Aristarchus | Aristotle | Svante Arrhenius | Oswald Avery | Amedeo Avogadro | Avicenna

Charles Babbage | Francis Bacon | Alexander Bain | John Logie Baird | Joseph Banks | Ramon Barba | John Bardeen | Charles Barkla | Ibn Battuta | William Bayliss | George Beadle | Arnold Orville Beckman | Henri Becquerel | Emil Adolf Behring | Alexander Graham Bell | Emile Berliner | Claude Bernard | Timothy John Berners-Lee | Daniel Bernoulli | Jacob Berzelius | Henry Bessemer | Hans Bethe | Homi Jehangir Bhabha | Alfred Binet | Clarence Birdseye | Kristian Birkeland | James Black | Elizabeth Blackwell | Alfred Blalock | Katharine Burr Blodgett | Franz Boas | David Bohm | Aage Bohr | Niels Bohr | Ludwig Boltzmann | Max Born | Carl Bosch | Robert Bosch | Jagadish Chandra Bose | Satyendra Nath Bose | Walther Wilhelm Georg Bothe | Robert Boyle | Lawrence Bragg | Tycho Brahe | Brahmagupta | Hennig Brand | Georg Brandt | Wernher Von Braun | J Harlen Bretz | Louis de Broglie | Alexander Brongniart | Robert Brown | Michael E. Brown | Lester R. Brown | Eduard Buchner | Linda Buck | William Buckland | Georges-Louis Leclerc, Comte de Buffon | Robert Bunsen | Luther Burbank | Jocelyn Bell Burnell | Macfarlane Burnet | Thomas Burnet

Benjamin Cabrera | Santiago Ramon y Cajal | Rachel Carson | George Washington Carver | Henry Cavendish | Anders Celsius | James Chadwick | Subrahmanyan Chandrasekhar | Erwin Chargaff | Noam Chomsky | Steven Chu | Leland Clark | John Cockcroft | Arthur Compton | Nicolaus Copernicus | Gerty Theresa Cori | Charles-Augustin de Coulomb | Jacques Cousteau | Brian Cox | Francis Crick | James Croll | Nicholas Culpeper | Marie Curie | Pierre Curie | Georges Cuvier | Adalbert Czerny

Gottlieb Daimler | John Dalton | James Dwight Dana | Charles Darwin | Humphry Davy | Peter Debye | Max Delbruck | Jean Andre Deluc | Democritus | René Descartes | Rudolf Christian Karl Diesel | Diophantus | Paul Dirac | Prokop Divis | Theodosius Dobzhansky | Frank Drake | K. Eric Drexler

John Eccles | Arthur Eddington | Thomas Edison | Paul Ehrlich | Albert Einstein | Gertrude Elion | Empedocles | Eratosthenes | Euclid | Eudoxus | Leonhard Euler

Michael Faraday | Pierre de Fermat | Enrico Fermi | Richard Feynman | Fibonacci – Leonardo of Pisa | Emil Fischer | Ronald Fisher | Alexander Fleming | John Ambrose Fleming | Howard Florey | Henry Ford | Lee De Forest | Dian Fossey | Leon Foucault | Benjamin Franklin | Rosalind Franklin | Sigmund Freud | Elizebeth Smith Friedman

Galen | Galileo Galilei | Francis Galton | Luigi Galvani | George Gamow | Martin Gardner | Carl Friedrich Gauss | Murray Gell-Mann | Sophie Germain | Willard Gibbs | William Gilbert | Sheldon Lee Glashow | Robert Goddard | Maria Goeppert-Mayer | Thomas Gold | Jane Goodall | Stephen Jay Gould | Otto von Guericke

Fritz Haber | Ernst Haeckel | Otto Hahn | Albrecht von Haller | Edmund Halley | Alister Hardy | Thomas Harriot | William Harvey | Stephen Hawking | Otto Haxel | Werner Heisenberg | Hermann von Helmholtz | Jan Baptist von Helmont | Joseph Henry | Caroline Herschel | John Herschel | William Herschel | Gustav Ludwig Hertz | Heinrich Hertz | Karl F. Herzfeld | George de Hevesy | Antony Hewish | David Hilbert | Maurice Hilleman | Hipparchus | Hippocrates | Shintaro Hirase | Dorothy Hodgkin | Robert Hooke | Frederick Gowland Hopkins | William Hopkins | Grace Murray Hopper | Frank Hornby | Jack Horner | Bernardo Houssay | Fred Hoyle | Edwin Hubble | Alexander von Humboldt | Zora Neale Hurston | James Hutton | Christiaan Huygens | Hypatia

Ernesto Illy | Jan Ingenhousz | Ernst Ising | Keisuke Ito

Mae Carol Jemison | Edward Jenner | J. Hans D. Jensen | Irene Joliot-Curie | James Prescott Joule | Percy Lavon Julian

Michio Kaku | Heike Kamerlingh Onnes | Pyotr Kapitsa | Friedrich August Kekulé | Frances Kelsey | Pearl Kendrick | Johannes Kepler | Abdul Qadeer Khan | Omar Khayyam | Alfred Kinsey | Gustav Kirchoff | Martin Klaproth | Robert Koch | Emil Kraepelin | Thomas Kuhn | Stephanie Kwolek

Joseph-Louis Lagrange | Jean-Baptiste Lamarck | Hedy Lamarr | Edwin Herbert Land | Karl Landsteiner | Pierre-Simon Laplace | Max von Laue | Antoine Lavoisier | Ernest Lawrence | Henrietta Leavitt | Antonie van Leeuwenhoek | Inge Lehmann | Gottfried Leibniz | Georges Lemaître | Leonardo da Vinci | Niccolo Leoniceno | Aldo Leopold | Rita Levi-Montalcini | Claude Levi-Strauss | Willard Frank Libby | Justus von Liebig | Carolus Linnaeus | Joseph Lister | John Locke | Hendrik Antoon Lorentz | Konrad Lorenz | Ada Lovelace | Percival Lowell | Lucretius | Charles Lyell | Trofim Lysenko

Ernst Mach | Marcello Malpighi | Jane Marcet | Guglielmo Marconi | Lynn Margulis | Barry Marshall | Polly Matzinger | Matthew Maury | James Clerk Maxwell | Ernst Mayr | Barbara McClintock | Lise Meitner | Gregor Mendel | Dmitri Mendeleev | Franz Mesmer | Antonio Meucci | John Michell | Albert Abraham Michelson | Thomas Midgeley Jr. | Milutin Milankovic | Maria Mitchell | Mario Molina | Thomas Hunt Morgan | Samuel Morse | Henry Moseley

Ukichiro Nakaya | John Napier | Giulio Natta | John Needham | John von Neumann | Thomas Newcomen | Isaac Newton | Charles Nicolle | Florence Nightingale | Tim Noakes | Alfred Nobel | Emmy Noether | Christiane Nusslein-Volhard | Bill Nye

Hans Christian Oersted | Georg Ohm | J. Robert Oppenheimer | Wilhelm Ostwald | William Oughtred

Blaise Pascal | Louis Pasteur | Wolfgang Ernst Pauli | Linus Pauling | Randy Pausch | Ivan Pavlov | Cecilia Payne-Gaposchkin | Wilder Penfield | Marguerite Perey | William Perkin | John Philoponus | Jean Piaget | Philippe Pinel | Max Planck | Pliny the Elder | Henri Poincaré | Karl Popper | Beatrix Potter | Joseph Priestley | Proclus | Claudius Ptolemy | Pythagoras

Adolphe Quetelet | Harriet Quimby | Thabit ibn Qurra

C. V. Raman | Srinivasa Ramanujan | William Ramsay | John Ray | Prafulla Chandra Ray | Francesco Redi | Sally Ride | Bernhard Riemann | Wilhelm Röntgen | Hermann Rorschach | Ronald Ross | Ibn Rushd | Ernest Rutherford

Carl Sagan | Abdus Salam | Jonas Salk | Frederick Sanger | Alberto Santos-Dumont | Walter Schottky | Erwin Schrödinger | Theodor Schwann | Glenn Seaborg | Hans Selye | Charles Sherrington | Gene Shoemaker | Ernst Werner von Siemens | George Gaylord Simpson | B. F. Skinner | William Smith | Frederick Soddy | Mary Somerville | Arnold Sommerfeld | Hermann Staudinger | Nicolas Steno | Nettie Stevens | William John Swainson | Leo Szilard

Niccolo Tartaglia | Edward Teller | Nikola Tesla | Thales of Miletus | Theon of Alexandria | Benjamin Thompson | J. J. Thomson | William Thomson | Henry David Thoreau | Kip S. Thorne | Clyde Tombaugh | Susumu Tonegawa | Evangelista Torricelli | Charles Townes | Youyou Tu | Alan Turing | Neil deGrasse Tyson

Harold Urey

Craig Venter | Vladimir Vernadsky | Andreas Vesalius | Rudolf Virchow | Artturi Virtanen | Alessandro Volta

Selman Waksman | George Wald | Alfred Russel Wallace | John Wallis | Ernest Walton | James Watson | James Watt | Alfred Wegener | John Archibald Wheeler | Maurice Wilkins | Thomas Willis | E. O. Wilson | Sven Wingqvist | Sergei Winogradsky | Carl Woese | Friedrich Wöhler | Wilbur and Orville Wright | Wilhelm Wundt

Chen-Ning Yang

Ahmed Zewail

Return to top of page

Famous Scientists - Privacy - Contact - About - Content & Imagery © 2025